Foscarnet is an antiviral agent with a broad spectrum inhibiting all known human viruses of the herpes group: herpes simplex virus type 1 and 2; human herpes virus 6; varicella zoster virus; Epstein-Barr virus and cytomegalovirus (CMV) and some retroviruses, including human immunodeficiency virus (HIV) at concentrations not affecting normal cell growth. Foscarnet also inhibits the viral DNA polymerase from hepatitis B virus.

Indication:

1. Induction and maintenance therapy of cytomegalovirus (CMV) retinitis in patients with AIDS.
2. Treatment of mucocutaneous Herpes Simplex Virus (HSV) infectious, clinically unresponsive to acyclovir in immunocompromised patients.
   
   

Note: Foscarnet is also used in Valganciclovir/ ganciclovir/ acyclovir resistance cytomegalovirus (CMV) infections in transplant recipient.

Dosage Forms and Strengths

24 mg/ml solution for infusion 6000 mg/250 mL bottle