It indicated for the treatment of :

• Metastatic breast cancer: after failure of combination chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated.
• Locally advanced or metastatic non-small cell lung cancer (NSCLC):  as first-line treatment in combination with carboplatin, in patients who are not candidates for curative surgery or radiation therapy.